III Frontiers in membrane Protein Structural Dynamics
APS Conference Center, Argonne National Lab

Friday, November 10

7:45 Continental Breakfast, APS 402 Atrium
8:15 Eduardo Perozo (University of Chicago), Stephen Streiffer (Advanced Photon Source)
Welcome and overall perspective

Session I: ABC Transporters and Partners: Dynamics at the Edge of Stability

8:25 Christine Ziegler (Universität Regensburg)
8:30 Doug Rees (Caltech University)
ABC transporters and the alt-access movement
8:55 Show-Ling Shyng (Oregon Health & Science University)
Illumination of the SUR1-Kir6.2 partnership in KATP channels by single-particle cryo-EM
9:20 Heather Pinkett (Northwestern University)
The role of ABC transporters in nutrient uptake and pathogenesis
9:45 Break, APS 402 Atrium

Session II: Technology Advances in Protein Expression and Engineering

10:25 Chris Ahern (University of Iowa)
10:30 Anthony Kossiakoff (University of Chicago)
Synthetic Antibodies to facilitate structural analyses of functional conformational intermediates by both crystallography and Cryo-EM
10:55 Bill Clemons (Caltech University)
Solving the membrane protein expression problem
11:20 Andrew Kruse (Harvard University)
New technologies to interrogate membrane protein function
11:45 Lunch, APS 402 – Lower Gallery

Session III: Pumping Ions and Other Flotsam

1:00 Francisco Bezanilla (University of Chicago)
1:05 Bernd Fakler (University of Freiburg, Germany)
Native PMCAs – proteomic surprises with old Ca2+-pumps
1:30 Miguel Holmgren (National Institutes of Health)
Dynamics of the Na/K ATPase with the binding/unbinding of external Na ions
1:55 Huan Rui (University of Chicago)
Probing the cycling mechanism of the P-type ATPase: Insights from kinetic modeling simulations
2:20 Break, APS 402 Atrium

Session IV: Poster Rapid Fire

2:50 Yeon-Kyun Shin (Iowa State University)
2:55 Poster presenters
2 minute talks

Session V: Keynote Speaker 1

4:45 A Brief Vignette Honoring Jean Chin (Eduardo Perozo, University of Chicago)
5:00 Alessio Accardi (Weill Cornell University)
5:10 Christopher Miller (Brandeis University)
How channel crystallography made me stupid
6:00 Dinner, APS 402 – Lower Gallery
Posters, APS 402 – E1100/E1200

Saturday, November 11

Session VI: Calculating Conformational Changes: At the Bleeding Edge

7:45 Continental Breakfast, APS 402 Atrium
8:25 Wonpil Im (LeHigh University)
8:30 Benoit Roux (University of Chicago)
C-type Inactivation and the Constricted-Like Conformations of the Selectivity Filter of K+ Channels
8:55 Michael Grabe (University of California, San Francisco)
TMEM16 lipid scrambles bend membranes to get things done
9:20 Jose Faraldo-Gomez (National Institutes of Health)
The Dos and Don’ts of the Alternating-Access Mechanism: Lessons from the Sodium-Calcium Exchanger
9:45 Break, APS 402 Atrium

Session VII: Protein Motion Within a Field: Ins and Outs of Voltage-dependent Gating

10:25 Sudha Chakrapani (Case Western Reserve University)
10:30 Jian Yang (Columbia University)
Cryo-EM structure of a eukaryotic cyclic nucleotide-gated channel
10:55 Bonnie Wallace (Birbeck, University of London)
Structural, Function and Disease-Related Aspects of Sodium Channel Voltage-Gating
11:20 Francisco Bezanilla (University of Chicago)
Voltage sensors and membrane capacitance
11:45 Rama Ranganthan (University of Chicago)
Protein mechanics: the link between structure, function, and evolution
12:10 Lunch, APS 402 – Lower Gallery

Session VIII: Structure and Dynamics with Few Molecules (or a Lot)

1:25 Valeria Vasquez (University of Tennessee, Memphis)
1:30 Robert Fischetti (APS, Argonne National Lab)
Serial crystallography with monochromatic and polychromatic X-ray beams, and the APS Upgrade
1:55 Yeon-Kyun Shin (Iowa State University)
Zooming in on single vehicle fusion
2:20 Simon Scheuring (Weill Cornell University)
High-Speed Atomic Force Microscopy: A New Tool for the Study of the Dynamics of Single Unlabeled Membrane Proteins
2:45 Break, APS 402 Atrium
Posters, APS 401 – E1100/E1200

Session IX: The Good, the Bad and the Ugly: Conformational Changes and the Transport/Translocation Cycle

4:30 Ming Zhou (Baylor University)
4:35 Filipo Mancia (Columbia University)
The Molecular Mechanisms Underlying Cellular Uptake of Vitamin A
5:00 Aurelio Galli (University of Vanderbilt)
Failure to Prime the Dopamine ‘Pump’ in Autism
5:25 Alessio Accardi (Weill Cornell University)
Exploring the backdoor of CLC channels and transporters: how a glutamate gets in and out of the Cl- permeation pathway
5:50 Dinner, APS 402 – Lower Gallery
Posters, APS 401 – E1100/E1200

Sunday, November 12

Session X: Structural Dynamics Through Imaging

9:00 Tobin Sosnick (University of Chicago)
9:05 Christine Ziegler (Universität Regensburg)
Being in the right place: Localization-dependent lipid interactions in the PC2 TRP Channel
9:30 Irina Serysheva (University of Texas Houston)
Structure of IP3R Channel: Towards Understanding Gating Mechanism
9:55 Vera Moiseenkova-Bell (University of Pennsylvania)
Molecular mechanism of the TRPV2 channel pore dynamics during ligand activation
10:20 Mingley Zhao (University of Chicago)
Molecular Mechanism of SNARE Complex Disassembly
10:55 Break, APS 402 – Atrium

Session XI: Keynote Speaker 2

11:05 Robert Nakamoto (University of Virginia)
11:15 Olga Boudker (Weill Cornell University)
Dynamic underpinnings of transport mechanism in glutamate transporters


 *Shuttle service from the guest house to the conference center will start 15 minutes prior to the start of the meeting.

*Shuttle service from the conference center to the guest house will run for 15 minutes after the poster session (9:00pm).