May 19, 2018
Gordon Center for Integrative Science, University of Chicago
In the past few years, a revolution in cryo electron microscopy has taken structural biology by storm. The recent integration of new developments in electron microscopes, direct electron detection cameras, and advances in image analysis methods are allowing the expansion of high resolution structural molecular biology in new and exciting directions by direct visualization of macromolecules and their complexes. The next decades will be dominated by the study of protein-protein, protein-nucleic acid complexes, molecular machines, and their conformational changes in ways that were impossible before due to their size and/or the need to study them in crystalline form. In addition, developments in many aspects of electron microscopy are providing new tools for the study of biological molecules from the single molecule to the cellular level. The second Third Coast Workshop on Biological Cryo-EM will address key developments in this fast advancing field and will provide scientists from different disciplines with an opportunity to discuss the state of the field and exchange views from both experimental and computational perspectives.