A common diaryl ether intermediate for the gram-scale synthesis of oxazine and xanthene fluorophores

By Andrew V. Anzalone, Tracy Y. Wang, Zhixing Chen, and Virginia W. Cornish

Published in Angewandte Chemie International Edition 52(2):650-4 on January 7, 2013.
PMID: 23169599. PMCID: PMC3860831. Link to Pubmed page.

Core Facility: Membrane Protein Expression/Purification.


Copper-catalyzed coupling reactions can be used for the high-yielding preparation of widely used oxazine and xanthene fluorophores from a common diaryl ether intermediate on a gram-scale (see scheme). This general approach may facilitate the future development of novel fluorophores and probes with unique properties.