Membrane proteins play an essential role in controlling the movement of material and information in and out of the cell, in determining the flow and use of energy, as well as in triggering the initiation of numerous signaling pathways. To fulfill these roles, conformational and interaction dynamics exert a dominant influence on their functional behavior, for it is the interplay between structure and dynamics what ultimately defines their function.

The Membrane Protein Structural Dynamics Consortium (MPSDC) has been designed as a highly interactive, tightly integrated and multidisciplinary effort focused on elucidating the relationship between structure, dynamics and function in a variety of membrane proteins. This website serves as a gateway both to the Consortium's activities and resources, and to the scientific field at large.

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Transporter linked to autism risks

Membrane Protein Structural Dynamics Consortium (MPSDC) team member Hassane Mchaourab was recently featured in the Vanderbilt University Medical Center Reporter, along with a team of scientists who have linked a non-inherited, de novo mutation in the dopamine transporter to autism spectrum disorder (ASD). 

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Structural Refinement Based on EPR Data from Restrained-Ensemble Simulation

Recently, a novel computational simulation technique was developed to exploit the information from distance distribution data obtained from ESR/DEER spectroscopy for the refinement of membrane protein structures. Read more »
Video feature: Behind the scenes in Emad Tajkhorshid's laboratory
We sat down with Emad Tajkhorshid and asked him about his work with computational modeling, his lab's Consortium-wide collaborations, and his views on the role of the Consortium within the broader scientific community.

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