Core D3 (sAB core) Collaboration Summary – April 2014
Within the Consortium
| PI | Site | Target | Status |
| Eduardo Perozo | UChicago | CiVSD | Structure solved and published |
| CiVSD – functional mutants | Structure solved and published | ||
| “Open” and “Closed” KcsA | Structures solved and published | ||
| CorA | Selection completed, characterization in progress. | ||
| Jonathan Javitch | Columbia | LeuT WT and mutants | Terminated |
| Tony Kossiakoff | UChicago | hGH-BP 2:1 hGH complex | Functional characterization in progress |
| hPRLR-PRL complex | Structure solved. | ||
| Katherine Henzler-Wildman | Wash U | EmrE | Selection completed, characterization in progress. |
| Benoit Roux | UChicago | Tsuka channel | Selection completed, crystallization and characterization in progress. |
| Merritt Maduke | Stanford | ClC-ec1 | Selection completed, characterization in progress. |
| Hassane Mchaourab | Vanderbilt | Pgp | Provided consultation; target prep in progress. |
| Olga Boudker | Einstein | TSPO | Selection in Progress |
Outside the Consortium
| PI | Site | Target | Status |
| Tracy Handle | UCSD | CXCR7 | Selection in Progress |
| Dan Minor | UCSF | TRAAK | Selection in Progress |
| Robert Lamb | Northwestern | F-pre | Functional characterization finished |
| F-post | Functional characterization finished | ||
| HN | Functional characterization finished | ||
| NiF-pre | On hold | ||
| Bil Clemons | Caltech | TatC | Terminated |
| TatB-TatC translocase complex | Terminated | ||
| Robert Keenan | UChicago | Get3/TA | Structure solved |
| Get3/Get4 | Crystal screening in progress | ||
| MjX | Structure solved | ||
| Fran Ashcroft | Oxford | Sur2A Apo | Crystal screening in progress |
| Sur2A ATP complex | Crystal screening in progress | ||
| Sur2A Pinacidil complex | Crystal screening in progress | ||
| Sur2A Glibencamide complex | Crystal screening in progress | ||
| Sur2A P1075 complex | Crystal screening in progress | ||
| Senyoun Choe | Salk Institute | EnvZ osmomolarity sensor | Terminated |
| EnvZ kinase domain | Terminated | ||
| Daniel Rosenbaum | UT Southwestern | ABC transporters, cholesterol receptor | Selection completed; Characterization in progress. |
| Sangram Sisodia | UChicago | gamma-secretase | New domains in the necastrin subunit identified and work published; Crystal screening and functional characterization in progress |
| Alastair Barr | University of Westminster | DEP-1 | Two crystal structures determined Refinement in progress |
| CD45 | Functional characterization in progress | ||
| Min Lu | Rosalind Franklin Med | Bacterial multidrug transporters | Crystal structures determined and published; new sABs being tested for trapping different conformational states. |
| Chris Miller | Brandeis / HHMI | Fluoride channels. Chloride channels | sABs generated, functional characterization and structure determination in progress |
| Robert Lefkowitz | Duke | B2AR, arrestin | Structure determined and published |
| Brian Fox | Univ Wisconsin Madison | hSCD1 | Initial selections completed |
| PiID | Target prep in progress | ||
| Sigma-1 | Target prep in progress | ||
| Osamu Nureki | Univ of Tokyo | ChRFR | Selection completed; sAB characterization in progress |
| Robert Tampe | Goethe Univ | TAP1 | Selection completed; sAB characterization in progress |
| TAP2 | Selection completed; sAB characterization in progress | ||
| Andre Hoelz | Caltech | Nuclear pore complexes | Selection completed; sAB Structure solved, in refinement |
| Demet Arac-Ozkan | Univ Chicago | Adhesion GPCRs | Selection completed for 3 targets; Diffraction data collected; functional studies in progress. |
| Anirban Banerjee | NIH/NICHD | Mitoferrin | Target prep in progress |
| Susan Buchanan | NIH/NIDDK | Klebsiella pneumonia IgaA | Selection in progress |
| Youxing Jiang | UT Southwestern / HHMI | mitochondria Ca2+ uniporter | Selection in progress |
| Simon Newstead | Oxford Univ | nucleotide-sugar transporters | Target prep in progress |
