Professor, Department of Biochemistry and Molecular Biology and Institute for Biophysical Dynamics, The University of Chicago
A principle research interest of the Kossiakoff Lab centers on studying at atomic resolution the structural and functional properties that define molecular recognition systems that activate and regulate biological properties. In particular, these studies focus on delineating the energetics of hormone-induced receptor activation and regulation of growth hormone and its receptor using X-ray crystallography, site-directed mutagenesis, phage display mutagenesis and biophysical analysis. His group has pioneered with the Koide group the Chaperone-Assisted Crystallography technique. In complementary studies the Kossiakoff group is developing semi-synthetic cytokine receptor systems to study the role of protein dynamics on signaling function.